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目的 探讨凝血酶抑制剂低分子肝素治疗短暂性脑缺血发作患者的血液流变学及部分实验室指标改变及其临床意义。方法 将符合诊断标准的患者随机分为治疗组(A组)19 例,对照组(B组)20 例,检测两组的血液流变学变化及部分实验室指标,并将结果加以比较。结果 A组治疗前后全血粘度,血浆粘度,还原粘度及红细胞聚集指数均降低(P<0 .05),两组间治疗后比较差异有显著性(P<0. 05),实验室检查指标KPTT、PLT、BT、CT、AST、LDH、Cr均无显著变化(P>0. 05),两组间比较差异无显著性(P>0 .05)。结论 TIA的血粘度增高是微血栓形成的重要影响因素。
Objective To investigate the changes of hemorheology and some laboratory indexes of thrombin inhibitor low molecular weight heparin in patients with transient ischemic attack and its clinical significance. Methods Ninety-seven patients in the treatment group (group A) and 20 in the control group (group B) were randomly divided into two groups. The hemorheological changes and some laboratory indexes of the two groups were compared and the results were compared. Results Before and after treatment, the whole blood viscosity, plasma viscosity, reducing viscosity and erythrocyte aggregation index of group A were decreased (P <0.05), and there was significant difference between the two groups after treatment (P <0.05). The laboratory test index There were no significant differences in KPTT, PLT, BT, CT, AST, LDH and Cr between the two groups (P> 0.05). Conclusion TIA blood viscosity is an important factor influencing the formation of microthrombus.