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DPN患者106例,分为2组,全部病例给予甲钴胺治疗,治疗组另给予丁咯地尔缓释片每次0.6g,每天1次,共6个月,观察临床症状、神经传导速变和血液流变学、甲襞微循环指标的变化,并判断临床疗效。结果:显效率和总有效率治疗组分别为26.4%、81.1%,显著高于对照组的13.2%、54.7%(均为P<0.01),MNCV和SNCV经治疗后有显著提高,与对照组比较有显著性差异(P<0.01),血液流变学指标和甲襞微循环有明显改善。结论:盐酸丁咯地尔缓释片口服治疗DPN有较好疗效。
106 patients with DPN were divided into two groups, all cases were given mecobalamin treatment, the treatment group were given buflomedil sustained-release tablets each 0.6g, 1 day, a total of 6 months to observe the clinical symptoms, nerve conduction velocity Change and hemorheology, nailfold microcirculation index changes, and to determine the clinical efficacy. Results: The effective rate and total effective rate in treatment group were 26.4% and 81.1% respectively, significantly higher than those in control group (13.2% and 54.7%, both P <0.01). MNCV and SNCV significantly increased after treatment, There was significant difference (P <0.01), hemorheology index and nailfold microcirculation were significantly improved. CONCLUSION: Buflomedil hydrochloride sustained-release tablets are effective in the treatment of DPN.