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目的:观察加味柴胡疏肝散联合奥美拉唑和莫沙必利对胃食管反流病的影响。方法:选择胃食管反流病患者86例,随机分为治疗组与对照组,每组43例,治疗组给予加味柴胡疏肝散汤剂,每天1剂,奥美拉唑20mg,口服,每天2次,莫沙必利5mg,口服,每天3次;以及胃黏膜保护剂等药物治疗。对照组予以奥美拉唑、莫沙必利及胃黏膜保护剂等药物治疗。治疗4周后观察反酸、胸骨后灼痛、呕吐等症状及胃镜下黏膜改善情况。结果:治疗组对胃食管反流病的临床疗效优于对照组(P<0.05);两组均无明显不良反应。结论:加味柴胡疏肝散联合奥美拉唑和莫沙必利对胃食管反流病治疗效果良好。
Objective: To observe the effect of Modified Chaihu Shugan Powder Combined with Omeprazole and Mosapride on Gastroesophageal Reflux Disease. Methods: Eighty-six patients with gastroesophageal reflux disease were randomly divided into treatment group and control group, with 43 cases in each group. The treatment group was given Modified Chaihu Shugan Powder, one day, omeprazole 20mg, 2 times a day, mosapride 5mg, orally, 3 times a day; and gastric mucosal protective agents and other drug treatment. The control group was omeprazole, mosapride and gastric mucosal protective agents and other drug treatment. After 4 weeks of treatment, the symptoms of acid reflux, post-sternal burn, vomiting and mucosal improvement under endoscopy were observed. Results: The therapeutic effect of the treatment group on gastroesophageal reflux disease was better than that of the control group (P <0.05). No adverse reactions were observed in both groups. Conclusion: Modified Chaihu Shugan Powder combined omeprazole and mosapride on gastroesophageal reflux disease treatment effect.