论文部分内容阅读
目的:探讨低分子量肝素与脉络宁合用治疗急性脑梗死的临床疗效。方法:将101例急性脑梗死病人随机分成低分子量肝素组(33例,只用低分子量肝素),脉络宁组(34例,单用脉络宁)及两药合用组(34例)。低分子量肝素的用法为0.4mL脐周皮下注射,每12小时1次;脉络宁的用法为20mL加入到5%葡萄糖氯化钠溶液或0.9%氯化钠溶液250mL中静脉滴注,每日1次。3组均治疗14日。治疗前后分别进行神经功能缺损评分,检查血常规、肝功能、肾功能、凝血功能。结果:两药合用组显效率71%,有效率91%,均显著高于低分子量肝素组和脉络宁组(<0.05和<0.01,且未发现有严重的肝、肾功能损害及出血等不良反应。结论:低分子量肝素与脉络宁合用治疗急性脑梗死安全有效,疗效优于单用其中一种药物者。
Objective: To investigate the clinical effect of low molecular weight heparin combined with Mailuoning in the treatment of acute cerebral infarction. Methods: A total of 101 acute cerebral infarction patients were randomly divided into low molecular weight heparin group (33 cases, only low molecular weight heparin), Mailuoning group (34 cases, Mailuoning alone) and two drugs combined group (34 cases). The usage of low molecular weight heparin is subcutaneously injected subcutaneously 0.4mL umbilical once every 12 hours; Mailuoning 20mL added to 5% glucose sodium chloride solution or 0.9% sodium chloride solution 250mL intravenous infusion daily 1 Times. 3 groups were treated on the 14th. Before and after treatment were neurological deficit score, check the blood, liver function, renal function, coagulation function. Results: The effective rate of 71% and effective rate of 91% in the two combined groups were significantly higher than those in the low molecular weight heparin group and the Mailuoning group (<0.05 and <0.01), and no serious hepatic and renal dysfunction and hemorrhage were found Adverse reactions.Conclusion: The combination of low molecular weight heparin with Mailuoning is safe and effective in the treatment of acute cerebral infarction, and the curative effect is better than that of single drug alone.