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目的 探讨α1 抗胰凝乳蛋白酶基因 (ACT)A/T多态性和中国人群脑出血的相关性。方法 采用病例 对照研究方法 ,用聚合酶链反应 限制性片段长度多态性的方法检测 2 2 0例脑出血和2 76例健康对照者的ACT基因多态性 ,用多元Logistic回归模型分析与脑出血的相关性。结果 经年龄、性别、饮酒、吸烟、文化程度、糖尿病、高血压调整后 ,可见 (1)ACTAT、TT基因型导致脑出血发病危险性显著增加 (OR值分别为 2 33,2 17,P <0 0 5 ) ,但与高血压无相关性。 (2 )高血压导致脑出血发病危险性显著增加 (OR =8 17,P =0 0 0 0 )。 (3)ACTAT/TT和高血压对脑出血的发生有明显交互作用 ,显著增加脑出血的危险性 ,交互作用系数为 2 84 ,OR值为 15 92 ,为 4型交互作用中的超相乘模型。ACTAT/TT和糖尿病对脑出血的发生为 3型交互作用中的相加模型 ,OR值为 2 89。结论 ACT基因A/T多态性和高血压是脑出血发病的独立危险因素。AT/TT基因型和高血压及糖尿病对脑出血均有交互作用。
Objective To investigate the relationship between α1 antichymotrypsin gene (ACT) A / T polymorphism and cerebral hemorrhage in Chinese population. Methods A case-control study was conducted to detect ACT gene polymorphism in 220 cerebral hemorrhages and 2 76 healthy controls by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) Relevance of bleeding. Results (1) ACTAT and TT genotypes significantly increased the risk of developing cerebral hemorrhage (OR = 2 33,2 17, P < 0 0 5), but no correlation with hypertension. (2) The risk of hypertension caused by cerebral hemorrhage increased significantly (OR = 8 17, P = 0 0 0 0). (3) There was a significant interaction between ACTAT / TT and hypertension on the occurrence of cerebral hemorrhage, which significantly increased the risk of cerebral hemorrhage. The interaction coefficient was 2 84 and OR was 15 92. model. The incidence of cerebral hemorrhage with ACTAT / TT and diabetes mellitus was an additive model for type 3 interaction with an OR of 2 89. Conclusion ACT gene A / T polymorphism and hypertension are independent risk factors of cerebral hemorrhage. AT / TT genotype and hypertension and diabetes have an interaction on cerebral hemorrhage.