双链RNA依赖性蛋白激酶(PKR)是一个经典的干扰素可诱导蛋白,具有抗病毒活性,并参与了细胞信号转导、细胞生长、分化和凋亡等生理过程。此外,PKR在抗病毒的天然免疫应答中亦发挥着十分重要的调控作用。近来,越来越多的研究发现报道了与PKR相互作用的蛋白质,为阐明PKR功能的分子机制提供了重要依据。本文主要介绍了已被证实与PKR相互作用的蛋白质,并对PKR发挥作用的机制进行探讨。 Double-stranded RNA-dependent protein kinase (PKR) is a classical interferon-inducible protein with antiviral activity and is involved in physiological processes such as cell signal transduction, cell growth, differentiation and apoptosis. In addition, PKR plays a very important regulatory role in the antiviral natural immune response. Recently, more and more studies have found that proteins that interact with PKR have provided an important basis for clarifying the molecular mechanism of PKR function. This article describes the proteins that have been shown to interact with PKR and explores the mechanisms by which PKR plays a role.