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本文报道人胃低分化腺癌细胞(MGC-803)在外源性三磷酸腺苷(ATP)的连续作用下,细胞增殖受到明显的阻抑,4天以后细胞增殖的抑制率达80％以上,细胞内的骨架系统有较明显的改善。微管由中央区的微管组织中心一直伸展到细胞边缘附近,使细胞充分铺展并变扁平,近似于正常上皮细胞的形态。微丝束变粗壮,纵横交错,布满细胞周边的细胞质内。点状的肌动蛋白荧光明显减少。细胞内外的纤维粘连蛋白的荧光反应更加明显。本文并讨论了细胞增殖和细胞骨架系统之间的关系。
In this paper, we report that the proliferation of human gastric poorly-differentiated adenocarcinoma cells (MGC-803) was significantly inhibited by the continuous administration of exogenous adenosine triphosphate (ATP). After 4 days, the cell proliferation inhibition rate reached more than 80% Skeleton system has a more significant improvement. Microtubules from the central region of the microtubule tissue center has been extended to near the cell edge, so that cells fully spread and become flat, similar to the normal epithelial morphology. Microfilament becomes thicker, criss-cross, covered with cells around the cytoplasm. Dot-like actin fluorescence was significantly reduced. Fluorescence reaction of fibronectin inside and outside cell is more obvious. This article also discusses the relationship between cell proliferation and cytoskeletal systems.