Design,Synthesis and Synergistic Effects of Novel Derivatives of Solanesol

来源 :Chemical Research in Chinese Universities | 被引量 : 0次 | 上传用户:fengxuemin
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
To further explore the biological activities of solanesylamine derivatives,several novel solanesylpiperazinotriamines and their amides were designed and synthesized,the chemical structures of target compounds were confirmed by IR,1H NMR,MS,and element analysis.The in vitro antitumor activities of the synthetic compounds were assessed by MTT test on L1210 and CHO cells.The preliminary results showed that at low micromolar concentrations these compounds exhibit obvious toxicity against tumor cells,and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations,they also evidently enhance the curative effect of vincristine(VCR).The synergistic effects of compounds 4a,4c,and 9 were even superior to that of reference compound N,N’-bis(3,4-dimethoxybenzyl)-N-solanesyl-ethylenediamine(SDB). To further explore the biological activities of solanesylamine derivatives, several novel solanesylpiperazinotriamines and their amides were designed and synthesized, the chemical structures of the target compounds were confirmed by IR, 1H NMR, MS, and element analysis. In vitro antitumor activities of the synthetic compounds were assessed by MTT test on L1210 and CHO cells. The preliminary results showed that at low micromolar concentrations of these compounds exhibit obvious toxicity against tumor cells, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations, they also evidently enhance the curative effect of vincristine (VCR). The synergistic effects of compounds 4a, 4c, and 9 were even superior to that of reference compound N, N’-bis (3,4-dimethoxybenzyl) -N-solanesyl-ethylenediamine (SDB).
其他文献
2003年10月—2004年2月,我们用自制复方马蹄香颗粒治疗轮状病毒(rotavirus,RV)肠炎患儿50例,并与用西药必奇、金双歧的50例患者作对照,现报告如下。资料与方法1临床资料100例
张东荪,这是个当代人已然陌生的名字。在近代中国的历史舞台上,张东荪主要是以“政论家”的身份引领一时风骚,他不但积极输入西方各种社会政治思潮,更以一种“介入”的姿态月
医疗保险信息系统连通全市72家定点医院、3家银行;网上报税系统使整个报税过程只需数分钟,划款结果实时返回;高校毕业生就业网上报批系统由原来手工接收审批过程的3到5个工
经过一年多的筹备策划 ,以拥有著名“麒派”表演艺术家赵麟童等名家的浙江京剧团即将推出京剧麒派名家名剧展演暨“百朝麟风”演出季。从12月21日开始 ,一直到明年1月4日 ,相
传统的土壤强度测定方法均需直接接触土壤,该文提出一种利用微波反射效应测定土壤强度的遥测方法。采用一套简单的试验装置以测定土壤的微波反射损失并用之研究土壤的含水量
杨振宁教授的一生做出过许多重大的抉择,从求学美国到走进象牙之塔,从入籍美国再到访问祖国,他的这些抉择大都是非常务实与理智的,也是十分正确的。他唯一的失误是他与李政道
过去,质量好的彩色打印机价格昂贵,而那些支付得起的彩色打印机的输出质量又不能令人满意。但是,随着Canon的BJC-4200以及EPSON StylusColor 500的问世,这一格局发生了变化,
小时候,看电影是一件很愉快的事。花一、两根冰棍的钱,就可以进电影院。而更多的时候,连钱也不要,看免费的露天电影:天刚擦黑,甚至还没黑,场院上就早早的有人去占位置了。各
《老房子》以广大观众习惯和乐于接受的方式讲述了一个发生在西安城墙下一条小巷中的波澜起伏、引人入胜的故事,具有浓郁的古城地方特色,属于老百姓喜闻乐见的言情戏。它以