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Objective To observe the levels of HIF-αand TGF-βin the liver tissue,change of serum transaminase in different phases after paraquat(PQ)toxicity and liver histopathology change in PQ-induced liver toxicity of rat models in order to analyze the relationship between HIF-αand hepatic toxicity induced by PQ.Methods A total of 48 healthy SD rats were randomly(random number)assigned into 2 groups:PQ poisoning group(n=42,
Objective To observe the levels of HIF-α and TGF-βin the liver tissue, change of serum transaminase in different phases after paraquat (PQ) toxicity and liver histopathology change in PQ-induced liver toxicity of rat models in order to analyze the relationship between HIF -α and hepatic toxicity induced by PQ. Methods A total of 48 healthy SD rats were randomly assigned to 2 groups: PQ poisoning group (n = 42,