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目的:探讨脑血管狭窄病人血清中C-反应蛋白(C-reactivc protein,CRP)水平及其与胆固醇、尿酸的相关关系。方法:采用散射免疫比浊法分别测定本院神经内科脑血管狭窄住院病人106名通过脑血管造影术诊断的脑血管狭窄患者和42名通过颅脑血管颅脑多普勒检查的正常健康体检者血清中CRP的水平并进行相互比较。结果:脑血管狭窄组血清CRP水平明显高于对照组(狭窄<70%组:16.22±10.45vs4.21±3.01 mg/L狭窄>70%组:21.36±11.45vs4.21±3.01 mg/L,P<0.01),具有统计学意义。Logistic回归分析显示CRP和脑血管狭窄(>70%)有相关关系,有统计学意义。结论:CRP水平的升高,对严重脑血管狭窄患者病情的预测及观察有一定的价值。
Objective: To investigate the serum levels of C-reactive protein (CRP) and its correlation with cholesterol and uric acid in patients with cerebrovascular stenosis. Methods: 106 patients with cerebrovascular stenosis diagnosed by cerebrovascular angiography and 42 healthy subjects undergoing cranial cerebral Doppler examination were enrolled in this study. Serum levels of CRP were compared with each other. Results: Serum levels of CRP in cerebrovascular stenosis group were significantly higher than those in control group (stenosis <70%: 16.22 ± 10.45 vs 4.2 ± 3.01 mg / L stenosis> 70%: 21.36 ± 11.45 vs 4.2 ± 3.01 mg / L, P <0.01), with statistical significance. Logistic regression analysis showed that there was a significant correlation between CRP and cerebrovascular stenosis (> 70%). Conclusion: The increase of CRP level has some value in predicting and observing the severity of cerebrovascular stenosis.