1980年首次报告,血管内皮与血管扩张有关。目前血管内皮单位作为血管平滑肌张力调节系统的证据正在增加。培养的内皮细胞亦能生成和分泌血管收缩物质。如内皮素(endothelin),一种21——残基肽,已从猪和人细胞中分离出。本文作者测定了尿毒症患者血浆内皮素水平。研究48例尿毒症患者,男35例,女13例,其中37接受血透1～168月(平均55.9月),每周2～8次。另取19例非胰岛素依赖型糖尿病患者(NIDDM)为非尿毒症对照组。患者均平卧休息30分钟后抽血,15例血透者在血透结束后也抽血,血标本立即与5mg EDTA及抑肽酶500μ/ml相混合,经离心分离血浆,贮于-20℃直至测定。应用放免法测定血浆内皮素水平,正常值<3.5Pg/ml。结果 19例对照组中16例<3.5Pg/ml,血透尿毒症患者5.4～35.4Pg/ml,平均12.3(5.5)Pg/ml,显著高于对照组(P<0.001)。而非透析尿毒症患者血浆内皮素水平则较低。研究发现,尿毒症各组患者血浆内皮素水平与血尿素氮、血浆 First reported in 1980, vascular endothelial and vascular dilatation. The current evidence of vascular endothelial units as vascular smooth muscle tone regulating systems is increasing. The cultured endothelial cells also produce and secrete vasoconstrictors. Such as endothelin, a 21-residue peptide that has been isolated from pigs and human cells. The authors determined plasma endothelin levels in uremic patients. 48 cases of uremia patients, 35 males and 13 females, of which 37 hemodialysis from January to 168 months (mean 55.9 months), 2 to 8 times per week. Another 19 cases of non-insulin-dependent diabetes mellitus (NIDDM) were non-uremic control group. Patients were rest for 30 minutes after sucking blood, 15 hemodialysis patients after hemodialysis was also drawn blood, blood samples immediately with 5mg EDTA and aprotinin 500μ / ml phase, centrifuged plasma, stored at -20 ℃ until measured. Application of radioimmunoassay plasma endothelin levels, normal <3.5Pg / ml. Results 16 cases in control group (3.5Pg / ml, 5.4 ~ 35.4Pg / ml, mean 12.3 (5.5) Pg / ml) were significantly higher than those in control group (P <0.001). Non-dialysis uremic patients with plasma endothelin levels are lower. The study found that patients with uremia plasma endothelin levels and blood urea nitrogen, plasma