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目的:研究慢性化脓性中耳炎(CSOM)主要病原菌的种类及对抗生素的耐药情况。方法:对135例CSOM患者的中耳脓性分泌物进行细菌培养,对分离的病原菌进行药物敏感试验。结果:分离出病原菌119株,以金黄色葡萄球菌(45株)为主,其次是棒状杆菌 (17株)和真菌(13株)。金黄色葡萄球菌对青霉素、庆大霉素、奈替米星耐药率高,分别为94％、64％、61％,对喹诺酮类、利福平、万古霉素、磺胺类敏感性高。棒状杆菌对青霉素、氯洁霉素、磺胺类、苯唑西林耐药率高,分别为54％、60％、40％、 40％,对庆大霉素、环丙沙星、利福平、万古霉素、复方氨苄西林敏感性高。结论:金黄色葡萄球菌、棒状杆菌和真菌是CSOM的主要病原菌。革兰阳性球菌和革兰阴性杆菌对青霉素类抗生素耐药性均高,对喹诺酮类、利福平、万古霉素均敏感。表4参4
Objective: To study the types of major pathogens in chronic suppurative otitis media (CSOM) and their resistance to antibiotics. Methods: The middle ear purulent secretions from 135 patients with CSOM were cultured in vitro, and drug-sensitive tests were performed on the isolated pathogens. Results: 119 strains of pathogens were isolated, mainly Staphylococcus aureus (45 strains), followed by Corynebacterium (17 strains) and fungi (13 strains). Staphylococcus aureus to penicillin, gentamicin, netilmicin resistance rate were 94%, 64%, 61%, quinolones, rifampin, vancomycin, sulfa high sensitivity. Corynebacterium penicillin, clindamycin, sulfonamides, oxacillin resistance rates were high, respectively 54%, 60%, 40%, 40% of gentamicin, ciprofloxacin, rifampicin, Vancomycin, compound ampicillin high sensitivity. Conclusion: Staphylococcus aureus, coryneform bacteria and fungi are the main pathogens of CSOM. Gram-positive cocci and gram-negative bacilli are resistant to penicillin antibiotics and sensitive to quinolones, rifampicin and vancomycin. Table 4 Senate 4