报告作为动脉粥样硬化症模型动物的NJS系小鼠的培育历史与建系方法,包括基代来源、育种目标、技术原理、育种手段、繁殖方式、饲养管理等。并对近交过程中出现的繁殖性能下降和定向选择下血清胆固醇水平变化,以及所采用的培育方法和饲养管理措施的可行性进行了探讨。 To report on the history and methods of fostering NJS mice that are models of atherosclerosis, including the origin, breeding objectives, technical principles, breeding methods, breeding methods, breeding management and so on. In the process of inbreeding, the decrease of reproductive performance and the change of serum cholesterol levels under the directional selection were also discussed. The feasibility of breeding methods and feeding management methods were also discussed.