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目的:综合分析职业性铅暴露与女性生殖功能之间的关系,为制订防制措施提供科学依据。方法:通过计算机和手工检索,收集国内发表的关于职业性铅暴露与女工生殖功能关系的文献,按纳入和剔除标准严格筛选,采用Meta分析合并文献效应值,并进行一致性检验及发表偏倚检验。结果:共纳入17篇文献,职业性铅暴露与女性痛经关系的合并OR值(95%CI)为3.38(1.45,7.87)、周期异常的合并OR值(95%CI)为2.37(1.95,2.88),先兆流产的合并OR值(95%CI)为4.24(2.19,8.22),妊娠高血压的合并OR值(95%CI)为3.37(1.09-10.44),死产死胎的合并OR值(95%CI)为3.99(2.43,6.56),自然流产的合并OR值(95%CI)为3.10(2.17,4.43),新生儿低体重的合并OR值(95%CI)为4.47(2.78,7.21),畸形的合并OR值(95%CI)为3.63(2.12,6.22)。结论:女工职业性铅暴露可影响其生殖功能,应对其进一步采取保护措施。
OBJECTIVE: To comprehensively analyze the relationship between occupational lead exposure and female reproductive function and to provide a scientific basis for making prevention measures. Methods: The literature on the relationship between occupational lead exposure and female reproductive function published in China was collected by computer and manual retrieval. Strict screening was carried out according to inclusion and exclusion criteria. Meta-analysis was used to combine the literature effect values, and the consistency test and publication bias test . Results: A total of 17 articles were included. The combined odds ratio (95% CI) of occupational lead exposure and female dysmenorrhea was 3.38 (1.45 and 7.87), and the combined odds ratio (95% CI) of periodic abnormalities was 2.37 ). The combined odds ratio (95% CI) of threatened abortion was 4.24 (2.19,8.22), the combined OR (95% CI) of gestational hypertension was 3.37 (1.09-10.44), the combined OR of stillbirths (95% CI) were 3.10 (2.17, 4.43), and the combined OR (95% CI) of neonates with low weight was 4.47 (2.78, 7.21) , The combined deformity OR (95% CI) was 3.63 (2.12,6.22). Conclusion: Female occupational lead exposure can affect its reproductive function, and should take further protective measures.