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目的探讨高频环形电刀切除术(LEEP)联合干扰素-α保守治疗外阴上皮内瘤变(VIN),能否降低其复发率。方法选取2004年9月至2008年8月在中国医科大学附属第一医院就诊VIN患者12例,其中外阴鲍文样丘疹病8例,外阴鲍文氏病4例。病灶>5mm者行局部病灶切除后LEEP射频治疗,病灶≤5mm者直接LEEP射频治疗。术后外阴局部皮下注射干扰素-α30μg,每周2次,共5次,之后改为隔日肌肉注射,共5～10次。结果12例患者治疗后2～3周创面基本愈合,未见有新病灶出现。随访5～54个月(中位随访时间21个月),均未见复发。结论LEEP射频联合干扰素-α外阴局部皮下注射治疗VIN方法可行,能降低其复发率。
Objective To investigate whether conservative treatment of vulvar intraepithelial neoplasia (VIN) with high-frequency annular electrotectomy (LEEP) and interferon-α can reduce its recurrence rate. Methods From September 2004 to August 2008, 12 patients with VIN were admitted to the First Affiliated Hospital of China Medical University, including 8 cases of vulvar abalone papulosis and 4 cases of vulvar and Bowen’s disease. Lesions> 5mm were treated with LEEP radiofrequency ablation of the lesion, direct LEEP radiofrequency treatment of lesions ≤ 5mm. Postoperative vulva local subcutaneous injection of interferon-α 30μg, 2 times a week for a total of 5 times, then replaced by intramuscular injection every other day, a total of 5 to 10 times. Results The wounds of 12 patients basically healed 2 to 3 weeks after treatment, and no new lesions were seen. All patients were followed up for 5 to 54 months (median follow-up time was 21 months). No recurrence was found. Conclusions LEEP combined with interferon-α subcutaneous local subcutaneous injection of VIN method feasible, can reduce the recurrence rate.