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神经内分泌多肽在休克的发生和发展中具有重要意义。本实验采用放射免疫法观察大剂量地塞米松对犬失血性休克以及血浆心钠素、精氨酸加压素的影响。休克后对照组血浆心钠素浓度呈进行性降低;治疗组平均动脉压在6.6 kPa、3.3 kPa时血浆心钠素浓度回升至原有水平。
Neuroendocrine peptides in the occurrence and development of shock is of great significance. In this study, radioimmunoassay was used to observe the effects of high-dose dexamethasone on hemorrhagic shock in dogs and plasma atrial natriuretic peptide and arginine vasopressin. After the shock, the plasma atrial natriuretic peptide concentration decreased progressively in the control group. When the mean arterial pressure was 6.6 kPa and 3.3 kPa in the treatment group, the plasma atrial natriuretic peptide level returned to its original level.