论文部分内容阅读
目的:观察糖疏康对DOP大鼠骨代谢、骨密度及骨生物力学影响。方法:健康大鼠40只,空白对照组10只,其余大鼠腹腔内注射链脲佐菌素造糖尿病模型,成模后随机分成治疗组、西药对照组与病理组各10只。分别给予糖疏康、碳酸钙片、阿法迪三和生理盐水灌胃给药。12周后取材,测血清钙、磷、血清骨源性碱性磷酸酶、骨T-羧基谷氨酸蛋白、骨密度、骨矿含量、骨的生物力学指标。结果:实验性DOP大鼠上述指标均明显异常。糖疏康治疗后有明显缓解,综合疗效优于碳酸钙片和阿法迪三。结论:糖疏康能明显改善糖尿病性骨质疏松大鼠的一般状况;降低血糖;调节体内Ca、P、BALP与BGP的代谢;显著增加骨密度及骨矿含量;提高骨干重、骨灰重及骨钙量;改善生物力学特性等作用;糖疏康对DOP大鼠骨代谢具有多途径、多环节的有效调节作用。糖疏康治疗DOP确切疗效。
Objective: To observe the effect of Tangsutang on bone metabolism, bone mineral density and bone biomechanics in DOP rats. Methods: Forty healthy rats and 10 blank control rats were injected intraperitoneally with streptozotocin to induce diabetes mellitus. The rats were randomly divided into treatment group (n = 10) and control group (n = 10). Were given saccharidan, calcium carbonate tablets, Afatin three and saline gavage. Twelve weeks later, serum calcium, phosphorus, serum alkaline phosphatase, bone T-glucoprotein, bone mineral density, bone mineral content and bone biomechanics were measured. Results: The above indexes in experimental DOP rats were obviously abnormal. After the treatment of sugar sparse significantly relieved, the comprehensive effect is better than calcium carbonate and Alfa three. Conclusion: Tangshukang can significantly improve the general condition of diabetic rats with osteoporosis; reduce blood glucose; regulate the metabolism of Ca, P, BALP and BGP in vivo; significantly increase the bone mineral density and bone mineral content; increase the dry weight of bone, Bone calcium; improve biomechanical properties and other effects; sugar Shukang DOP rats with multiple pathological bone metabolism, effective regulation of multiple links. Danshui treatment of DOP the exact effect.