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目的:基于Excel建立一种简便的计算静脉注射给药药物动力学参数和隔室模型的方法。方法:采用残数法原理,利用Excel统计函数,逐步求解药物动力学参数和隔室模型参数。结果:基于Excel可直观演示静脉注射给药药动学参数和隔室模型参数计算过程,结果与教材一致。结论:基于残数法原理,Excel统计函数可用于临床教学或实验中药物动力学参数计算。
OBJECTIVE: To establish a simple and convenient method for calculating pharmacokinetic parameters and compartmental model of intravenous injection based on Excel. Methods: Using the principle of residuals method, using Excel statistical function, the pharmacokinetic parameters and compartment model parameters were solved step by step. Results: Based on Excel, the pharmacokinetic parameters of intravenous injection and the calculation of compartment model parameters can be directly demonstrated. The results are consistent with the teaching materials. Conclusion: Based on the principle of residuals method, Excel statistical function can be used to calculate pharmacokinetic parameters in clinical teaching or experiment.