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The analytical electron microscopy (AEM) was employed to observe the intratissuelar distribution of polysorbate 80 coated nanoparticles in brain with copper chlorophyll (CC), and a safe and cheap pigment was used as a marker. AEM analyses show that some nanoparticles are located at the wall of the microvasculum in brain, while others are distributed around the microvasculum in brain. These results may support that T-80 coated nanoparticles cross the BBB through mechanisms of endocytosis or transcytosis.
The analytical electron microscopy (AEM) was employed to observe the intratissuelar distribution of polysorbate 80 coated nanoparticles in brain with copper chlorophyll (CC), and a safe and cheap pigment was used as a marker. AEM analyzes show that some nanoparticles are located at the wall of the microvasculum in brain, while others are distributed around the microvasculum in brain. These results may support that T-80 coated nanoparticles cross the BBB through mechanisms of endocytosis or transcytosis.