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目的:探讨杨桃叶总黄酮对糖尿病大鼠模型的血糖影响。方法:小鼠腹腔注射四氧嘧啶80 mg.kg-1,大鼠腹腔注射链脲佐菌素40 mg.kg-1复制高血糖模型,随机分为模型对照(蒸馏水)组、格列本脲对照(0.3 g.kg-1)组、杨桃叶总黄酮高、中、低剂量(0.8,0.4,0.2 g.kg-1)组,另设空白组(蒸馏水)每组10只。连续灌胃7 d,末次药后1.5 h采血,测定动物的空腹血糖和葡萄糖耐量。结果:杨桃叶总黄酮高、中剂量显著降低高血糖模型大鼠和小鼠的空腹血糖,提高模型大鼠和小鼠的葡萄糖耐量。结论:杨桃叶总黄酮具有改善链脲佐菌素或四氧嘧啶诱发的高血糖和糖耐量作用。
Objective: To investigate the effect of total flavonoids of Carambola leaf on blood glucose of diabetic rats. Methods: Allo-pyrimidine 80 mg.kg-1 was intraperitoneally injected into the mice and the model of hyperglycemia was induced by intraperitoneal injection of streptozotocin (40 mg · kg-1). The rats were randomly divided into model control group (distilled water), glibenclamide Control (0.3 g.kg-1) group, total flavonoids of carambola leaves in high, medium and low doses (0.8,0.4,0.2 g.kg-1) group, another set of blank group (distilled water) of 10. Continuous gavage 7 d, 1.5 h after the last dose of blood, the fasting blood glucose and glucose tolerance of animals were measured. Results: High and medium dose of total flavonoids of carambola leaves significantly reduced fasting blood glucose in hyperglycemic rats and mice, and increased glucose tolerance in model rats and mice. Conclusion: The total flavonoids of carambola leaves can improve the hyperglycemia and glucose tolerance induced by streptozotocin or alloxan.