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亲溶酶体剂——十二烷基吗啡啉(N-dodecyl morpholine,NDM)体外对小鼠白血病L_(7811)细胞系细胞有明显的杀灭作用,其100％杀死10~6个/mlL_(7811)细胞浓度为15mg/ml。用此浓度NDM处理含5％L_(7811)细胞的615小鼠骨髓细胞后回输给615小鼠,对照组存活天数为16.3±1.78d,溶剂组为15.8士2.32d,而NDM处理组可长期存活(>40d)。615小鼠在接受致死剂量(800rad)照射后输注经NDM处理的含5％L_(7811)细胞的615小鼠骨髓细胞,小鼠不死于白血病而死于放射病,当输注细胞数加倍时,小鼠存活期从8.75土1.13d延长到10.68±0.99d(P<0.01)。
N-dodecylmorpholine (NDM) has a significant killing effect on murine leukemia cell line L117811 in vitro, killing 100% of 10 ~ 6 cells / The cell concentration of mlL_ (7811) was 15 mg / ml. Six hundred and sixty-six mouse bone marrow cells were treated with 5% L_ (7811) cells in this concentration of NDM and then transfused to 615 mice. The survival time of the control group was 16.3 ± 1.78d and that of the solvent group was 15.8 ± 2.32d, while the NDM treatment group Long-term survival (> 40d). 615 mice were transfused with NDM-treated 615 mouse bone marrow cells containing 5% L_ (7811) cells after a lethal dose (800 rad) of irradiation. The mice died of leukemia without leukemia and died of radiation sickness. When the number of infused cells was doubled , The survival of mice was prolonged from 1.13 days of 8.75 soil to 10.68 ± 0.99 days (P <0.01).