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目的探讨Maspin蛋白在子宫内膜样腺癌中的表达及其临床意义。方法采用免疫组化Envision TM二步法,检测67例子宫内膜样腺癌、30例子宫内膜不典型增生、18例正常子宫内膜组织中Maspin蛋白的表达情况。结果Maspin蛋白在正常子宫内膜组织、子宫内膜不典型增生、子宫内膜样腺癌中的阳性表达率分别为16.67%(3/18)、40.00%(12/30)、68.66%(46/67),3组比较,有显著性差异(χ2=18.17,P<0.05),Maspin蛋白表达与子宫内膜样腺癌的分期、脉管浸润和淋巴结转移相关,与患者年龄、组织学分级和肌层浸润深度无关。结论Maspin蛋白在子宫内膜样腺癌中呈高表达,但随着肿瘤的发展其表达水平下调,其在子宫内膜癌的发生、发展和转移过程中起着一定调控作用。
Objective To investigate the expression of Maspin protein in endometrioid adenocarcinoma and its clinical significance. Methods The expression of Maspin protein in 67 cases of endometrioid adenocarcinoma, 30 cases of endometrial dysplasia and 18 cases of normal endometrium were detected by immunohistochemical Envision TM two-step method. Results The positive rates of Maspin protein in normal endometrium, endometrial dysplasia and endometrial adenocarcinoma were 16.67% (3/18), 40.00% (12/30), 68.66% (46) / 67). There was significant difference between the three groups (χ2 = 18.17, P <0.05). The expression of Maspin protein was correlated with the stage, vascular invasion and lymph node metastasis of endometrial adenocarcinoma, And the depth of myometrial invasion has nothing to do. Conclusion Maspin protein is overexpressed in endometrial adenocarcinoma, but its expression is down-regulated with tumor development. It plays a regulatory role in the development, progression and metastasis of endometrial carcinoma.