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目的:检测第10染色体同源丢失性磷酸酶张力蛋白基因(phosphatase and tension homology delet echromo-someten,PTEN)在不同类型子宫内膜腺上皮细胞中的表达。方法:采用免疫组化检测不同类型子宫内膜组织中PTEN的表达。结果:(1)PTEN的表达在增生期和分泌期子宫内膜无差异(P>0.05)。(2)不典型增生与单纯性增生、不典型增生与复杂性增生相比,PTEN表达均有显著性差异(P<0.01),而单纯性增生与复杂性增生之间无显著差异(P>0.05)。(3)子宫内膜样腺癌中:尽管PTEN表达在<50岁年龄组大于≥50岁组,≤1/2肌层浸润深度组大于>1/2组,但其间均无显著性差异(皆P>0.05)。随着癌细胞分化程度的降低和分期的升高,PTEN表达有逐渐降低的趋势,但不同分化程度的癌组织之间和Ⅰ期、Ⅱ期与Ⅲ～Ⅳ期之间均无显著差异(P>0.05)。结论:PTEN表达降低促使了癌前病变的发生,可能是引起内膜细胞癌变的机制之一,PTEN表达与临床病理学特征关系不大。
Objective: To detect the expression of PTEN in different types of endometrial glandular epithelial cells. Methods: The expression of PTEN in different types of endometrium was detected by immunohistochemistry. Results: (1) There was no difference in the expression of PTEN between proliferative stage and secretory stage (P> 0.05). (2) The expressions of PTEN in atypical hyperplasia and simple hyperplasia, atypical hyperplasia and complex hyperplasia were significantly different (P <0.01), but there was no significant difference between simple hyperplasia and hyperplasia (P> 0.05). (3) In endometrioid adenocarcinoma, although there was no significant difference in the expression of PTEN between> 50 years old group> 50 years old and> 1/2 myometrial invasion depth group> 1/2, All P> 0.05). With the decrease of cancer cell differentiation and the increase of staging, the expression of PTEN tended to decrease gradually, but there was no significant difference between the different differentiation degree of cancerous tissues and between stage Ⅰ, Ⅱ and Ⅲ ~ Ⅳ (P > 0.05). Conclusion: The decreased expression of PTEN promotes the development of precancerous lesions and may be one of the mechanisms that cause the carcinogenesis of endometrial cells. The expression of PTEN is not related to clinicopathological features.