肿瘤细胞增殖迅速,缺氧是一种常见现象,肿瘤细胞适应缺氧微环境的主要机制包括改善肿瘤组织的能量代谢以及诱导新血管生成等,其中缺氧诱导因子-1(hypoxia in-ducible factor-1α,HIF-1α)、葡萄糖转运蛋白-1(glucosetransporter1,Glut-1)起着重要作用。目前有关乳腺癌肿瘤组织H Rapid proliferation of tumor cells, hypoxia is a common phenomenon, the tumor cells to adapt to hypoxia microenvironment, including the main mechanisms include improving the energy metabolism of tumor tissue and induction of new blood vessel formation, including hypoxia in-ducible factor -1α, HIF-1α) and Glucosetransporter1 (Glut-1) play an important role. Currently about breast cancer tissue H