对272例各种疾病患者及81例正常人以ELISA方法测定了ACA水平。结果表明,活动期SLE、RF阳性的RA、SS、PSS以及各种感染性疾病患者血清IgG-ACA阳性率分别为66％、38％、100％、50％及44%;IgM-ACA阳性率分别为53％、46％、20％、50％及42％。而非活动期SLE、RF阴性的RA及其它疾病患者的ACA均值及阳性率与正常人无显著差异,提示ACA与SLE等疾病病情的严重性及活动性有关,并可作为提示感染及监督疗效的一个参考指标。 ACA levels were measured by ELISA in 272 patients with various diseases and 81 healthy controls. The positive rates of serum IgG-ACA in active SLE, RF positive RA, SS, PSS and various infectious diseases were 66%, 38%, 100%, 50% and 44% respectively. The positive rates of IgM-ACA Respectively 53%, 46%, 20%, 50% and 42%. The ACA mean and positive rate of ACA in patients with active SLE, RF negative RA and other diseases were not significantly different from those in normal subjects, suggesting that ACA was related to the severity and activity of SLE and other diseases and could be used as a guideline for infection and surveillance A reference index