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目的:探讨胃肠道间质瘤的诊断和免疫组化结果。方法:收集我院1995～2005年手术切除的胃肠道非上皮性肿瘤存档的36份病例进行研究。结果:典型的平滑肌和神经来源的肿瘤CD117和CD34阴性,间质瘤是Desmin和Actin阳性反应以外CD117、CD34均为阳性表达,神经来源的肿瘤NSE和S-100均阳性表达。结论:间质瘤(GIST)是消化道最常见的间叶源性肿瘤,间质瘤的生物学特点与胃肠平滑肌瘤和神经鞘瘤不同,免疫组化常表达CD117、CD34。
Objective: To investigate the diagnosis and immunohistochemistry of gastrointestinal stromal tumors. Methods: A total of 36 cases of gastrointestinal non-epithelial tumors surgically resected from 1995 to 2005 in our hospital were collected. Results: The typical smooth muscle and nerve-derived tumors were negative for CD117 and CD34. The stromal tumors were positive for both CD117 and CD34 except for Desmin and Actin positive tumors. NSE and S-100 positive neuroblastoma were all positive. Conclusion: GIST is the most common mesenchymal tumor in the digestive tract. The biological features of stromal tumors are different from that of gastrointestinal leiomyoma and schwannoma. Immunohistochemistry often expresses CD117 and CD34.