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与传统给药方法相比,透皮给药可在较长时间内维持血药浓度相对稳定,避免肝脏首过作用,减小由于代谢不同所造成的个体差异,在提高疗效的同时减小毒副作用。有关的研究认为,现用药物的2/3有可能发展为透皮吸收剂型。但透皮给药必须克服完整皮肤首先是角质层的正常屏障机能,因此合理使用安全有效的促渗剂,才能使多种药物皮肤给药成为可能。我们利用放射性同位素示踪技术,对几种新合成的促渗剂对具有清热去火、
Compared with the traditional method of administration, transdermal administration can maintain a relatively stable plasma concentration over a long period of time, avoid the first pass of the liver, reduce the individual differences caused by different metabolites, reduce the toxicity while improving the curative effect side effect. Relevant studies suggest that two-thirds of existing drugs may develop into transdermally absorptive dosage forms. However, the transdermal administration must overcome the normal barrier function of the intact skin, the stratum corneum in the first place. Therefore, it is possible to use a safe and effective penetration enhancer in order to make multiple drug delivery to the skin. We use radioisotope tracer technology, several new synthetic penetration enhancers have a heat to the fire,