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为进一步探讨在群众性治疗血吸虫病中吡喹酮的适宜剂量和疗程,进行了临床比较研究。706例血吸虫病患者随机分为三组:1.总剂量50mg/kg,疗程1天,238例;2.总剂量60mg/kg,疗程2天,244例;3.总剂量72mg/kg,疗程3天,224例。每天剂量分3次服。为客观地评价药物副作用,其中336例在服吡喹酮前、后共3～5天给予酵母片作为安慰剂进行自身对照比较。 所有患者除2例外均按期足量完成疗程,主要药物副作用为头昏、头痛、乏力等。逐日观察各组药物副作用发生率无显著差异,而吡喹酮则与酵母片的有显著差异。治毕除2例心电图发现早搏外,血、尿常规,肝、肾功能,脑电图,肌电图均无异常变化。治毕6个月粪便毛蚴孵化阴转率三组分别为1.00％(131/131)、96.9％(126/130)及99.2(127/128)。结果表明三组的疗效及药物副作用相仿。因此,总剂量50mg/kg的一天疗法在群众性治疗中同样可取。
In order to further explore the appropriate dose and course of praziquantel in mass treatment of schistosomiasis, a clinical comparative study was conducted. 706 patients with schistosomiasis were randomly divided into three groups: 1. The total dose of 50mg / kg, course of 1 day, 238 cases; 2. The total dose of 60mg / kg, course of 2 days, 244 cases; 3. The total dose of 72mg / kg, 3 days, 224 cases. Daily dose of 3 times service. In order to objectively evaluate the side effects of the drugs, 336 patients were treated with praziquantel for 3 to 5 days before taking yeast tablets as a placebo for self-comparison. All patients except two cases were completed on schedule, the main side effects of drugs for dizziness, headache, fatigue and so on. Daily observation of the incidence of side effects in each group was no significant difference, while praziquantel and yeast tablets were significantly different. In addition to two cases of ECG found premature beats, blood, urine, liver, kidney function, EEG, EMG showed no abnormal changes. After 6 months of treatment, the hatchability of fecal cecropia hatching was 1.00% (131/131), 96.9% (126/130) and 99.2 (127/128), respectively. The results show that the three groups of similar efficacy and drug side effects. Therefore, a one-day total dose of 50 mg / kg is equally desirable in mass therapy.