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本文建立了羟乙基芦丁血浆浓度的反相高效液相色谱－多重峰共积分测定法。ＫｉｏｍａｓｉｌＣ１８固定相，流动相为甲醇－水－冰乙酸（３０∶６０∶１０）；线性范围为１～４０μｇ／ｍｌ，线性相关系数为０．９９８，方法平均回收率为９７±５．４％；常用配伍药物对测定基本无干扰。经测定３例患者的血浆浓度，证明本方法操作快速简便，重现性良好。
In this paper, a reversed-phase high performance liquid chromatography-multiple peak co-integration assay was developed for the determination of hydroxyethyl rutin in plasma. The linear range was 1 ~ 40μg / ml, the linear correlation coefficient was 0.998. The average recoveries of the method were 97 ± 5.4%. The mobile phase consisted of methanol - water and glacial acetic acid (30:60:10) Commonly used drugs on the determination of the basic interference. The plasma concentrations of 3 patients were measured, which proved that the method was rapid and easy to operate with good reproducibility.