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Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl_2 with no halo-removed occurred.
Several 6-aminoquinoline derivatives, which have been used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as an optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl_2 with no halo-removed occurred.