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目的 :探讨C反应蛋白 (CRP)增高在心房颤动 (房颤 )发病中的意义。方法 :应用免疫比浊法测定 96例诊断为房颤患者血清CRP水平 ,与对照组比较 ,并对房颤按持续时间、病因不同分设亚组 ,进行统计学分析。结果 :房颤组、对照组血清CRP水平分别为 (4 .30± 2 .87)、(1.15± 0 .90 )mg L ,两组相比P <0 .0 5。器质性、孤立性房颤者CRP水平分别为 (5 .0 6± 1.92 )、(4 .37± 1.32 )mg L ,均高于对照组 ,P <0 .0 5。持续性、永久性房颤者CRP水平分别为 (5 .6 0± 1.80 )、(5 .0 0± 1.6 0 )mg L ,均高于阵发性房颤 [(3.30± 1.2 0 )mg L],P <0 .0 5。结论 :CRP增高反映的炎症状态可能促进房颤发生 ,以及呈持续性发作。
Objective: To investigate the significance of elevated C-reactive protein (CRP) in the pathogenesis of atrial fibrillation (AF). Methods: Serum CRP level was measured in 96 patients diagnosed as atrial fibrillation by immunoturbidimetry. Compared with the control group, atrial fibrillation was divided into subgroups with different durations and etiologies for statistical analysis. Results: Serum CRP levels in AF group and control group were (4.30 ± 2.87) and (1.15 ± 0.90) mg L, respectively, P <0.05 compared with those in control group. The levels of CRP in organic and isolated atrial fibrillation were (5.60 ± 1.92) and (4.37 ± 1.32) mg L, respectively, which were higher than those in control group (P <0.05). The levels of CRP in persistent and permanent AF were (5.60 ± 1.80) and (5.00 ± 1.6 0) mg L, respectively, higher than those in patients with paroxysmal atrial fibrillation [(3.30 ± 1.2 0) mg L ], P <0. 0 5. CONCLUSIONS: The inflammatory state reflected by increased CRP may contribute to the occurrence of atrial fibrillation and persistent attack.