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目的:研究痛必定注射液对CCI(坐骨神经慢性结扎损伤)大鼠外周血清中NO含量的影响。方法:运用硝酸还原酶法,分别测量给药前后大鼠外周血清中NO的含量,通过对比,研究痛必定注射液对CCI大鼠外周血清中NO含量的影响。结果:痛必定注射液能显著降低CCI大鼠外周血清中NO的含量。结论:痛必定通过抑制CCI大鼠外周血清中NO的生成或释放,达到镇痛作用。
Objective: To study the effect of Tongbiding Injection on the content of NO in peripheral blood of rats with CCI (chronic constriction injury of sciatic nerve). Methods: Nitric acid reductase method was used to measure the content of NO in the peripheral blood of rats before and after the administration. The effect of Tongbiding Injection on the content of NO in the peripheral blood of CCI rats was studied. Results: Tongbiding injection can significantly reduce the content of NO in peripheral blood of CCI rats. Conclusion: Pain must be achieved by inhibiting the production or release of NO in the peripheral blood of CCI rats.