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目的：探讨综合护理干预在老年重症肺炎并发呼吸机相关性肺炎患者中的临床应用效果。方法：随机抽取本院收治的 80 例老年重症肺炎并发呼吸机相关性肺炎患者进行研究，以 2019 年 6 月-2020 年 5 月为研究起止时间。以随机抽签法分组，各 40 例。对照组患者给予常规护理，观察组在对照组基础上以综合护理干预。对比分析护理效果。结果：观察组患者机械通气时间、住院时间均较对照组短（P<0.05）；观察组患者并发症发生率及死亡率均低于对照组（P<0.05）；观察组干预后肺功能指标均优于对照组（P<0.05）。结论：综合护理应用在老年重症肺炎并发 VAP 患者中，可提升疾病改善效果，缩短治疗时间，有效避免各种并发症发生，积极改善患者的肺功能，临床应用价值高。“,”Objective: To explore the clinical effect of comprehensive nursing intervention in elderly patients with severe pneumonia complicated with ventilator-associated pneumonia. Methods: 80 elderly patients with severe pneumonia complicated with ventilator-associated pneumonia from June 2019 to may 2020 were selected and divided into two groups, 40 cases in each group. The control group was given routine nursing, and the observation group was given comprehensive nursing intervention on the basis of the control group. Comparative analysis of nursing effect. Results: the mechanical ventilation time and hospitalization time of the observation group were shorter than those of the control group (P < 0.05); the incidence of complications and mortality of the observation group were lower than those of the control group (P < 0.05); the pulmonary function indexes of the observation group after intervention were better than those of the control group (P < 0.05). Conclusion: the application of comprehensive nursing in elderly patients with severe pneumonia complicated with VAP can improve the effect of disease improvement, shorten the treatment time, effectively avoid various complications, actively improve the lung function of patients, and has high clinical application value.