论文部分内容阅读
目的研究儿童系统性红斑狼疮(JSLE)患者甲状腺功能异常发病情况及临床表现,探讨JSLE合并甲状腺功能异常与狼疮活动性及自身抗体的关系。方法 2010年1月至2013年8月首都医科大学附属北京儿童医院162例新发JSLE患者,检查其甲状腺功能,若异常则检测甲状腺球蛋白抗体(TG-Ab)、甲状腺微粒体抗体(TM-Ab)及甲状腺B超。统计学分析甲状腺功能异常与正常者的狼疮疾病活动性指数(SLEDAI)及抗核抗体(ANAs)滴度。结果 162例患者中61例甲状腺功能异常,其中4例为桥本甲状腺炎,57例仅T3减低,无明显临床症状。其中6例(9.8%)TG-Ab及TM-Ab阳性。甲状腺功能异常组SLEDAI显著高于与甲状腺功能正常组(P<0.05)。两组ANAs滴度差异无统计学意义(P>0.05)。结论 JSLE常合并甲状腺功能减低。甲状腺功能减低者狼疮活动性较甲状腺功能正常者高,需积极治疗。监测甲状腺功能及甲状腺抗体对JSLE患者非常重要。
Objective To study the incidence and clinical manifestations of thyroid dysfunction in children with systemic lupus erythematosus (JSLE) and to explore the relationship between JSLE complicated with thyroid dysfunction and lupus activity and autoantibodies. Methods A total of 162 newly diagnosed JSLE patients at Beijing Children’s Hospital, Capital Medical University from January 2010 to August 2013 were enrolled in this study. Their thyroid function was examined. Thyroglobulin antibody (TG-Ab), thyroid microsomal antibody (TM- Ab) and thyroid B ultrasound. Statistical analysis of lupus disease activity index (SLEDAI) and anti-nuclear antibody (ANAs) titers in patients with thyroid dysfunction and normal. Results 61 cases of 162 patients with abnormal thyroid function, including 4 cases of Hashimoto’s thyroiditis, 57 cases decreased only T3, no obvious clinical symptoms. Six cases (9.8%) were positive for TG-Ab and TM-Ab. SLEDAI was significantly higher in patients with abnormal thyroid function than those with normal thyroid function (P <0.05). There was no significant difference in the titer of ANAs between the two groups (P> 0.05). Conclusion JSLE often associated with hypothyroidism. Hypothyroidism, lupus activity than those with normal thyroid function, need active treatment. Monitoring thyroid function and thyroid antibodies is very important for patients with JSLE.