Rho/Rho激酶信号通路是体内普通存在的一条信号转导通路,它通过调节细胞内肌动蛋白骨架的聚合状态参与多种细胞功能,包括细胞收缩、迁移、黏附、增殖、凋亡及基因表达等。Rho/Rho激酶信号通路的异常激活在冠心病的发病机制和病理生理中发挥了重要作用,对此信号转导通路的研究可以为冠心病的预防和治疗提供新的靶点。现就Rho/Rho激酶信号通路的特征及其与冠心病的关系作一综述。 The Rho / Rho kinase signaling pathway is a common signal transduction pathway in the body. It participates in various cellular functions, including cell contraction, migration, adhesion, proliferation, apoptosis and gene expression, by regulating the polymerization state of intracellular actin cytoskeleton Wait. Abnormal activation of Rho / Rho kinase signaling pathway plays an important role in the pathogenesis and pathophysiology of coronary heart disease, and the study of signal transduction pathway may provide a new target for the prevention and treatment of coronary heart disease. Now on the Rho / Rho kinase signaling pathway and its relationship with coronary heart disease are reviewed.