论文部分内容阅读
本文重点介绍有机药物的分子构型和优势构象。其中包括顺反异构和手性分子产生的原因;Z/E和R/S构型的转变及其与药物化学稳定性的关系,碳环药物的优势构象;杂环药物中孤对电子的方位及端基效应等。
This article focuses on the molecular configuration of organic drugs and the dominant conformation. Including the causes of trans-and trans-isomerism and chiral molecules; the transition of Z / E and R / S configurations and their relationship with the chemical stability of drugs; the dominant conformations of carbocyclic drugs; the lone pairs of electrons in heterocyclic drugs Azimuth and end effect and so on.