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The aim of this study was to evaluate the effects of low concentrations of DEHP and MEHP on steroidogenesis in a murine Leydig tumor cell line(MLTC-1)in vitro.The result of fow cytometry analysis revealed that the proportion of apoptotic cells was signifcantly increased after the exposure to DEHP.All three genes(P450scc,P450c17,and3βHSD)under study showed an increased expression following exposure to DEHP or MEHP,although some insignificant inhibitory effects appeared in the 10μmol/L treatment group as compared with the controls.It was also found that
The aim of this study was to evaluate the effects of low concentrations of DEHP and MEHP on steroidogenesis in a murine Leydig tumor cell line (MLTC-1) in vitro. The result of fow cytometry analysis revealed that the proportion of apoptotic cells was signifcantly increased after the exposure to DEHP. All three genes (P450scc, P450c17, and3βHSD) under study showed an increased expression following exposure to DEHP or MEHP, although some insignificant inhibitory effects were found in the 10 μmol / L treatment group as compared with the controls. It was also found that