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目的:探讨布地奈德联合盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法:150例符合纳入标准的AECOPD患者随机分为2组,每组各75例。对照组给予盐酸氨溴索治疗,观察组在对照组的基础上联合使用布地奈德治疗。比较两组治疗疗效及治疗前后血气分析变化情况。结果:观察组的治疗总有效率为92.0%,明显高于对照组78.7%的治疗总有效率,比较有统计学差异(p<0.05)。血气分析方面,治疗前,两组患者PH值、PaO2和PaCO2比较无统计学差异(p均>0.05)。治疗后,与对照组相比,观察组PH值和PaO2明显升高,而PaCO2明显降低,比较都有统计学意义(p均<0.05)。结论:布地奈德联合盐酸氨溴索治疗AECOPD疗效可靠,可以提高治疗有效率,有效改善酸中毒,提高血氧分压,降低二氧化碳分压,值得临床进一步推广。
Objective: To investigate the efficacy of budesonide combined with ambroxol hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: One hundred and fifty patients with AECOPD who met the inclusion criteria were randomly divided into two groups with 75 cases in each group. The control group was treated with ambroxol hydrochloride. The observation group was treated with budesonide on the basis of the control group. The curative effects of the two groups were compared and the changes of blood gas analysis before and after treatment were compared. Results: The total effective rate of the observation group was 92.0%, which was significantly higher than 78.7% of the control group, with a statistically significant difference (p <0.05). Blood gas analysis, before treatment, the two groups of patients PH value, PaO2 and PaCO2 no significant difference (p all> 0.05). After treatment, compared with the control group, the observation group PH and PaO2 increased significantly, while PaCO2 significantly reduced, compared with statistical significance (all P <0.05). Conclusion: The efficacy of budesonide combined with ambroxol hydrochloride in the treatment of AECOPD is reliable, which can improve the treatment efficiency, effectively improve the acidosis, improve the partial pressure of oxygen and lower the partial pressure of carbon dioxide, which deserves further clinical promotion.