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2-氯-N-(2-氯-4-甲基-3-吡啶基)烟酰胺与环丙胺于室温在氯化亚铜催化下偶联,所得N-(2-氯-4-甲基-3-吡啶基)-2-环丙胺基烟酰胺在碱性条件下闭环即可得到抗病毒药奈韦拉平,总收率达82%。
The coupling of 2-chloro-N- (2-chloro-4-methyl-3-pyridyl) nicotinamide with cyclopropylamine at room temperature under cuprous chloride catalysis gave N- (2- -3-pyridyl) -2-cyclopropylamine Nicotinamide was closed-loop under alkaline conditions to get the antiviral drug nevirapine, with a total yield of 82%.