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The title compound N-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-quinoxaline-2-methanamide(4, C23H27N5O3, Mr = 421.50) was synthesized via a four-step reaction and characterized by 1H NMR, 13 C NMR, ESIMS and single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 12.108(2), b = 12.639(3), c = 14.601(3) , β = 104.87(3)o, V = 2159.6(8) 3, Z = 4, Dc = 1.296 g/cm3, S = 1.023, μ = 0.088 mm-1, F(000) = 896, R = 0.0392 and w R = 0.0983 for 2836 observed reflections with I > 2σ(I). The single-crystal X-ray structural analysis reveals that 4 is stabilized by intramolecular and intermolecular hydrogen bonds together with π-π interactions. The bioassay showed that 4 exhibited high selective activity for α1A/D vs. α1B-adrenoceptors subtype.
The title compound N- (2-hydroxy-3- (4- (2-methoxyphenyl) piperazin-1 -yl) propyl) -quinoxaline-2-methanamide (4, C23H27N5O3, Mr = 421.50) reaction and characterized by 1H NMR, 13 C NMR, ESIMS and single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21 / n with a = 12.108 (2), b = 12.639 (3), c = 14.601 (3) β β = 104.87 (3) o V = 2159.6 (8) 3 Z = 4 Dc = 1.296 g / cm3 S = 1.023 μ = 0.088 mm-1 F , R = 0.0392 and w R = 0.0983 for 2836 observed reflections with I> 2σ (I). The single-crystal X-ray structural analysis reveals that 4 is stabilized by intramolecular and intermolecular hydrogen bonds together with π-π interactions. The bioassay showed that 4 exhibited high selective activity for α1A / D vs. α1B-adrenoceptors subtype.