目的　观察降纤酶治疗急性脑梗死的临床疗效及安全性。方法　在发病 2 4h使用降纤酶治疗急性脑梗死 6 7例 ,同时与注射等容生理盐水的对照组 72例脑梗死作对照研究。结果　降纤酶治疗后血浆纤维蛋白原 (FIB)水平降低显著 ,临床神经功能显著改善 ,可能有出血并发症 ,两组比较无显著差异。结论　降纤酶治疗急性脑梗死安全可靠。 Objective To observe the clinical efficacy and safety of defibrase in the treatment of acute cerebral infarction. Methods A total of 67 acute cerebral infarction patients were treated with defibrase at 24 hours after the onset of disease, and 72 cases of cerebral infarction were injected with saline as control. Results After defibrase treatment, the level of plasma fibrinogen (FIB) decreased significantly, the clinical neurological function was significantly improved, and bleeding complications were likely. There was no significant difference between the two groups. Conclusion Defibrase in the treatment of acute cerebral infarction is safe and reliable.