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目的对抑郁症共病糖尿病患者血清同型半胱氨酸水平(Hcy)进行对照研究。方法首次确诊糖尿病的抑郁症患者(共病组,n=40)测定血清Hcy水平;同时测定空腹血糖(FPG)、糖负荷后2小时血糖(2hPG)、评定17项汉密尔顿抑郁量表(HAMD),并与正常糖代谢状态的抑郁症患者(对照组,n=40)进行对照。结果①共病组血清Hcy水平[(20±6)μmol/L]显著高于对照组[(13±4)μmol/L],差异有统计学意义(t=6.139,P<0.001);②共病组高Hcy血症的发生率(62.5%)显著高于对照组(32.5%),差异有统计学意义(χ2=7.218,P<0.01);③共病组、对照组的血清Hcy水平与FPG、2hPG、HAMD17评分均无显著的相关性(r=0.163~0.288,P均>0.05)。结论与正常糖代谢功能的抑郁症患者相比,伴发糖尿病的抑郁患者血清同型半胱氨酸水平显著增高。
Objective To compare the serum homocysteine level (Hcy) in patients with comorbid depression and depression. Methods Serum Hcy levels were measured in patients with first diagnosis of diabetes mellitus (n = 40). Fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG) were measured and 17 Hamilton Depression Rating Scale (HAMD) , And compared with those with normal glycometabolism (control group, n = 40). Results ① The level of Hcy in comorbidity group was significantly higher than that in the control group [(20 ± 6) μmol / L [(13 ± 4) μmol / L], the difference was statistically significant (t = 6.139, P <0.001) The incidence of hyperhomocysteinemia in comorbidity group was significantly higher than that in control group (62.5% vs 32.5%, χ2 = 7.218, P <0.01) There was no significant correlation between FPG, 2hPG and HAMD17 scores (r = 0.163 ~ 0.288, P> 0.05). Conclusions Serum homocysteine levels were significantly higher in depressed patients with diabetes than in those with normal glucose metabolism.