bromodomain是一进化上高度保守约 1 1 0个氨基酸的蛋白质功能结构域 ,可特异性识别组蛋白末端乙酰化的赖氨酸位点 ,通过染色质的组装和乙酰化而参与信号依赖性的、非基础性的基因转录调控 ;bromodomain亦可通过对转录因子等非组蛋白的乙酰化修饰而广泛参与细胞周期调控、细胞分化、信号转导等过程 ;bromodomain蛋白的改变通过组蛋白乙酰化的失调控参与了白血病等恶性肿瘤的发生 ,其与肿瘤关系的研究将为肿瘤治疗提供新的策略。 Bromodomain is a protein functional domain that is highly conserved about 110 amino acids. It specifically recognizes the acetylated lysine site at the end of histones and participates in signal-dependent, Non-basic gene transcription regulation; bromodomain can also participate in cell cycle regulation, cell differentiation, signal transduction and other processes through acetylation modification of non-histone such as transcription factor; bromodomain protein change through the loss of histone acetylation Regulatory participation in the occurrence of leukemia and other malignancies, and its relationship with the tumor research will provide a new strategy for cancer treatment.