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1.The basics of miRNA-mediated regulation The plasticity of skeletal muscle is of utmost importance for responding to and coping with environmental demands that emerge from changes in physical activity patterns,nourishment, hormonal status,and health.As is well known,a sedentary lifestyle,aging,immobilization,and chronic diseases are associated with reduced muscle mass and function,while regular exercise improves muscle function and reduces the rate of decrement throughout life.However,we do not have a complete understanding of the molecular factors controlling skeletal muscle adaptation to exercise stimuli.Recently identified microRNA molecules(miRNAs) have rapidly gained
1. The basics of miRNA-mediated regulation The plasticity of skeletal muscle is of utmost importance for responding to and coping with environmental demands that emerge from changes in physical activity patterns, nourishment, hormonal status, and health. As is well known, a sedentary lifestyle, aging, immobilization, and chronic diseases are associated with reduced muscle mass and function, while regular exercise improves muscle function and reduces the rate of decrement throughout life.However, we do not have a complete understanding of the molecular factors controlling skeletal muscle adaptation to exercise stimuli. Recently identified microRNA molecules (miRNAs) have rapidly gained