A set of molecule parameters, namely, N, N′, p, q, n, were used to express the structures of alkanes. A correlative model was established between certain physical-chemical properties and molecular parameters of alkanes by regression method. Eight physical-chemical properties, such as evaporation heat (Δ_vH~20_m), density(D~20), capacity(C~20), surface tension(σ~20), boiling point(T_b), critical temperature(T_c), critical pressure(P_c) and critical volume(V_c), of fifty-six C_3-C_16 alkanes were calculated directly from the model in this paper. The calculated values are in good accordance with the literature ones reported for alkanes, and the correlation coefficients (R) equal or exceed 0.99. The research results indicate that the principle of the method is simple and clear, the method is practical, the correlativity is excellent, and the predicted data are credible. A set of molecule parameters, namely, N, N ’, p, q, n, were used to express the structures of alkanes. A correlative model was established between certain physical-chemical properties and molecular parameters of alkanes by regression method. Eight physical --chemical properties, such as evaporation heat (Δ_vH ~ 20_m), density (D~20), capacity (C~20), surface tension (σ~20), boiling point (T_b), critical temperature (P_c) and critical volume (V_c), of fifty-six C_3-C_16 alkanes were calculated directly from the model in this paper. The calculated values ​​are in accordance with the literature first reported for alkanes, and the correlation coefficients (R) equal or exceed 0.99. The research results indicate that the principle of the method is simple and clear, the method is practical, the correlativity is excellent, and the predicted data is credible.