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为了深入探讨短程大量皮质激素疗法后下视丘脑-垂体-肾上腺轴的功能恢复情况,以指导临床使用,作者给10例正常人口服抑制剂量强的松5天(25mg,2次/日)后,观察下丘脑-垂体-肾上腺轴功能的恢复情况(对比治疗前和终止治疗后2天及5天试验者的肾上腺皮质对胰岛素诱发的低血糖以及对 ACTH 刺激后的反应)。试验发现,终止治疗后2天对低血糖和 KCTH 的反应,皮质醇分泌峰值分别从治疗前的20.6±1.6和27.3±2.5μg/dl 明显减小到11.0±0.9和13.3±1.4μg/dl(P<0.001)。但5天后皮质醇对低血糖的反应峰值即已接近治疗前水平,对 ACTH 的反应仅稍小于治疗前水平(22.3±
In order to further explore the functional recovery of the hypothalamic-pituitary-adrenal axis following a large dose of corticosteroid therapy in order to guide the clinical use, 10 normal subjects were dosed orally with prednisone for 5 days (25mg, twice daily) The recovery of hypothalamic-pituitary-adrenal axis function was observed comparing insulin-induced hypoglycemia in adrenocortical subjects and responses to ACTH stimulation at 2 days and 5 days after treatment. The trial found that the response to hypoglycaemia and KCTH 2 days after discontinuation of therapy was significantly reduced from 20.6 ± 1.6 and 27.3 ± 2.5 μg / dl before treatment to 11.0 ± 0.9 and 13.3 ± 1.4 μg / dl ( P <0.001). However, the peak of cortisol response to hypoglycemia after 5 days was close to pre-treatment level, and the response to ACTH was only slightly lower than before treatment (22.3 ±