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目的探讨特拉唑嗪对左氧氟沙星在大鼠前列腺炎组织中浓度的影响。方法建立SD雄性大鼠急性细菌性前列腺炎模型96只,随机分为单服左氧氟沙星组和联用特拉唑嗪组,每组48只,分别于给药后0.125、0.25、0.5、1、2、4、8和12h每个时间点活杀6只大鼠,采集2组动物的前列腺制作组织匀浆,HPLC法测定前列腺组织中的左氧氟沙星浓度,3p97软件计算药动学参数。结果单服左氧氟沙星组和联用特拉唑嗪组左氧氟沙星的药-时曲线均为二室模型。主要药动学参数如下:t1/2分别为(4.9±s1.4)和(7.9±2.0)h,tmax分别为(1.4±0.3)和(1.3±0.4)h,ρmax分别为(4.2±1.1)和(7.7±1.7)mg·kg-1,AUC0～12分别为(20±7)和(55±16)mg.h.kg-1。结论特拉唑嗪可提高左氧氟沙星在大鼠前列腺炎组织中的浓度。
Objective To investigate the effect of terazosin on the concentration of levofloxacin in rats with prostatitis. Methods 96 male SD rats with acute bacterial prostatitis were established. They were randomly divided into single levofloxacin group and terazosin group, with 48 rats in each group. The rats were randomly divided into two groups: 0.125,0.25,0.5,1,2 Six rats were sacrificed at 4, 8, and 12 hours. Prostates from two groups of animals were harvested for tissue homogenate. HPLC method was used to determine the concentration of levofloxacin in prostate tissue. Pharmacokinetic parameters were calculated by 3p97 software. Results The single-dose levofloxacin group and the combination of terazosin group levofloxacin drug-time curve are two-compartment model. The main pharmacokinetic parameters were as follows: t1 / 2 were (4.9 ± s1.4) and (7.9 ± 2.0) h, tmax was 1.4 ± 0.3 and 1.3 ± 0.4 h respectively, and ρmax were (4.2 ± 1.1) ) And (7.7 ± 1.7) mg · kg-1, respectively. The AUC0-12 was (20 ± 7) and (55 ± 16) mg.h.kg-1, respectively. Conclusion Terazosin can increase the concentration of levofloxacin in rats with prostatitis.