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目的观察盐酸格雷司琼对恶性血液病化疗时所致呕吐的防治作用。方法治疗组:盐酸格雷司琼3mg稀释后缓慢静脉注射,1次/d。片剂时为1mg2次/d,于化疗前1h服用第1片,12h后服用第2片,治疗60例次。对照组:甲氧氯普胺(胃复安)30～40mg静脉滴注,1次/d。治疗34例次。观察化疗过程中恶心呕吐的程度。结果治疗组明显优于对照组,差异具显著性。结论盐酸格雷司琼不仅能有效控制化疗时的胃肠道反应,而且是一种安全高效且作用持久、毒副反应小的理想止吐剂。
Objective To observe the prevention and treatment effect of Grebestron hydrochloride on vomiting induced by chemotherapy of malignant hematological diseases. Methods The treatment group: Granisetron hydrochloride 3mg diluted intravenously slowly, 1 time / d. Tablet 1mg2 times / d, taking 1h before chemotherapy 1h, 12h after taking the second film, the treatment of 60 cases. Control group: metoclopramide (metoclopramide) 30 ~ 40mg intravenous infusion, 1 time / d. Treatment of 34 cases. Observe the extent of nausea and vomiting during chemotherapy. Results The treatment group was significantly better than the control group, the difference was significant. Conclusion Grebesian hydrochloride not only can effectively control the gastrointestinal reaction during chemotherapy, but also is a safe and efficient and long-lasting, small toxic side effects of the ideal antiemetic.