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为了研究急性低氧对无氧代谢阈值的影响,本工作采用Wasserman的无损伤性方法,测定了11名健康男子分别在吸入气氧浓度为21%(常氧对照)、16.8%和12.8%时的无氧代谢阈值。结果表明,与常氧对照值(氧耗量,30.4±5.0ml/kg/min)相比较,吸入气氧浓度为16.8%时的无氧代谢阈值没有明显改变(31.6±5.4ml/kg/min);但是,当吸入气氧浓度降至12.8%时,无氧代谢阈值呈明显下降(25.7±2.2ml/kg/min)。12.8%低氧较常氧时,每分通气量和心率明显增加,而血氧饱和度和氧脉搏(氧耗量╱心率)明显降低。由低氧引起无氧代谢阈值的降低程度具明显个体差异。这一差异分别与他们在常氧时无氧代谢阈值的高低及低氧下氧脉搏的降低程度呈正相关(r=0.875,P<0.01;r=0.767,P<0.01),而与由低氧所引起的每分通气量,心率及血氧饱和度的改变之间没有相关性。轻度低氧时无氧代谢阈值无明显改变,但是当低氧加深时无氧代谢阈值会有明显降低。
In order to study the impact of acute hypoxia on the anaerobic metabolism threshold, Wasserman’s noninvasive method was used in this study to determine the effect of inhalation on the anaerobic metabolic threshold of 11 healthy men at inhaled oxygen concentrations of 21% (normoxia), 16.8% and 12.8%, respectively Anaerobic metabolism threshold. The results showed that there was no significant change in the anaerobic threshold (31.6 ± 5.4ml / kg / min) when oxygen concentration was 16.8% compared with normoxia control (oxygen consumption, 30.4 ± 5.0ml / kg / min) ); However, the threshold for anaerobic metabolism was significantly decreased (25.7 ± 2.2 ml / kg / min) when the inspired oxygen concentration dropped to 12.8%. 12.8% hypoxia compared with normoxia, minute ventilation and heart rate increased significantly, and oxygen saturation and oxygen pulse (oxygen consumption / heart rate) decreased significantly. There was a clear individual difference in the reduction of the threshold of anaerobic metabolism caused by hypoxia. This difference was positively correlated with the level of anaerobic metabolic threshold and the decrease of oxygen pulse under hypoxia (r = 0.875, P <0.01; r = 0.767, P <0.01) There was no correlation between minute ventilation, heart rate and changes in oxygen saturation. There was no significant change in the anaerobic metabolism threshold at mild hypoxia, but no significant reduction in hypoxia was observed when hypoxia progressed.