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目的:建立了神农香菊挥发油GC-MS指纹图谱分析测定方法,为神农香菊药材的质量控制提供参考。方法:采用水蒸气蒸馏法提取神农香菊挥发油,用GC-MS联用技术对神农香菊进行指纹图谱测定,并采用国家药品监督管理局推荐的中药指纹图谱计算软件进行计算,建立神农香菊挥发油的共有指纹图谱。结果:神农香菊挥发性成分中含有23个特征性指标成分,初步建立了以此23个共有峰为特征指纹信息的GC-MS指纹图谱。结论:该方法具有较好的重复性、精密度和稳定性(RSD均<5%),建立的神农香菊挥发油指纹图谱为其质量控制奠定了基础。
OBJECTIVE: To establish a method for the determination of volatile oil from Shennongxiangju by GC-MS fingerprinting, and to provide a reference for the quality control of Shennongxiangju. Methods: Volatile oil from Shennongxiangju was extracted by steam distillation. The fingerprint of Shennongxiangju was determined by GC-MS. The fingerprints of Shennongxiangju were calculated by the software of Chinese traditional medicine recommended by State Drug Administration. The common fingerprint of volatile oil. Results: The 23 volatile components of Shenxiang Chrysanthemum contained 23 characteristic components, and the fingerprint of GC-MS fingerprinted with 23 common peaks was preliminarily established. Conclusion: The method has good repeatability, precision and stability (RSD <5%). The established fingerprints of Shennongxiangju volatile oil laid the foundation for its quality control.